When Raphael died in 1520, a portrait was found in his studio of a local baker’s daughter named Margherita. She is thought to have been his lover — on his deathbead he had bid her farewell and arranged for her care.

The portrait might reveal something else as well. Writing in The Lancet in 2002, Georgetown University medical professor Carlos Hugo Espinel suggests that “La Fornarina” might have had breast cancer:

There is a bulge in the [left] breast that, beginning inward from the axilla and curving horizontally to the right, slopes gently toward the nipple. This bulge seems to be a mass, oval in shape, puckering just above the tip of La Fornarina’s index finger.

After studying other artworks, Espinel has also concluded that Michelangelo had gout, that Rembrandt died of temporal arteritis, and that the Mona Lisa’s smile may have resulted from the partial paralysis of a facial muscle. Independent research has supported some of these diagnoses.